Background Blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is an imaging method used to analyze oxygenation status of the tumor. Purpose To investigate the feasibility of BOLD-MRI in evaluating the efficacy of advanced cervical cancer combined with radiotherapy and chemotherapy. Material and Methods This prospective study included 85 patients with advanced cervical cancer who received BOLD-MRI examination before and after concurrent chemoradiotherapy from October 2020 to December 2021. To investigate the changes of baseline R2* values and △R2* values of cervical cancers before and after treatment. Results 29 cases were complete response, 34 cases were partial response, and 22 cases showed progression. The baseline R2* values of the tumors were lower than that of the normal cervical muscle ( P < 0.0001). After oxygen stimulation, the baseline R2* values of the tumors decreased ( P = 0.012). After treatment, the baseline R2* values of the tumors increased ( P = 0.007), and the dynamic △R2* values of the tumors decreased ( P = 0.025). The baseline R2* value of the complete response was the highest ( P = 0.000), the dynamic △R2* value of the complete response was the lowest ( P = 0.017). Conclusion BOLD-MRI can evaluate the efficacy of concurrent chemoradiotherapy for advanced cervical cancer.