According to the orthogonality of each sub-carrier in the multi-carrier phase-coded (MCPC) signal, this paper focuses on anti-interrupted sampling repeater jamming (ISRJ) and creatively proposes a novel radar signal based on time-frequency random coded (TFRC) method, namely TFRC-MCPC signal. Based on the perspective of waveform design, the TFRC-MCPC signal adopts a chaotic sequence with good pseudo-random to code each chip in time-domain and each subcarrier in frequencydomain. The TFRC method increases the pseudo-randomness of radar waveform pulses and reduces the correlation between radar echo and ISRJ, thereby effectively suppressing the interference of false targets. The TFRC-MCPC method and common filter design methods do not conflict with each other and can be used in combination. The simulation experiment results show that under the typical parameters described in the paper, compared with the traditional MCPC signal and LFM signal, the signaljamming ratio (SJR) improvement factor of the TFRC-MCPC signal is optimized by 1-2 dB after pulse compression, which verifies its feasibility and effectiveness.