Background: Coal miners are prone to burnout symptoms due to their special working environment. There are no studies on the correlation between job burnout and occupational stress, effort-reward imbalance, and work-family-conflict.Methods: In this cross-sectional study, 1,346 coal miners were selected from 5 coal mining companies using stratified cluster sampling method. The Chinese version of the Job Burnout Scale, Job Content Questionnaire (JCQ), Effort-Reward Inventory (ERI), and Working-Family-Conflict Scale were used to collect data from the coal miners. Correlation analysis and logistic regression methods were used to explore the factors affecting job burnout. Results: coal miners with different genders, ages, years of service, shift system, marital status, and type of work have different total scores and levels of job burnout (P<0.05). The effort-reward imbalance is associated with age, years of service, shift system and marital status (P<0.05). The occupational stress scores of coal miners of different genders, years of service, education, shift system and monthly income were different. Different shift systems, types of work, and work-family conflict scores were also different. The various dimensions of job burnout have varying degrees of correlation with the JCQ, ERI, and Working-Family-Conflict dimensions.Age, work demands, effort, work-family conflict and work-family conflict are risk factors for job burnout, and work autonomy is the protective factor. Conclusions:The detection rate of job burnout in coal miners in Xinjiang Uygur Autonomous Region is relatively high. Age, work demands, effort, and work-family conflict increase the incidence of job burnout, while work autonomy reduces job burnout.