From birth to 18 years, AMH increases, then it declines thereafter, indicating changes of ovarian maintenance. A positive relationship between androgenic profiles and AMH during adolescence and reproductive years implies a synchronism between androgens and ovarian reserve.

This research was supported by the National Basic Research Program of China (973 Program) (2012CB944700), Science research foundation item of no-earnings health vocation (201402004) and the National Natural Science Foundation of China (31471352, 81270662, 81471509, 81300461, 81522018). The authors have no potential conflict of interest to declare.

(Abstracted from Hum Reprod 2017:32:201–207) The underlying cause of primary ovarian insufficiency (POI) is unknown in most cases, which generally are referred to as idiopathic. Primary ovarian insufficiency is associated with biological reproductive aging and encompasses 3 stages: occult, biochemical, and overt.