In this work, long-circulating doxorubicin hydrochloride (Doc) liposomes were prepared by the of ammonium sulphate gradients with ethanol injection, and the methoxy polyethylene glycol (mPEG) was added to modify the membrane property of the liposomes. The long-circulating mPEG-modified Doc liposomes were nearly round with a particle size ranging from 50 to 70 nm. The entrapment efficiency of Doc was determined to be 57.53 %. Meanwhile, the experiment results indicated that the long-circulating Doc liposomes show good sustained release property.

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The elastic Euler buckling of an inextensible column is confined in a plane, and subject to fixed end displacement, in the presence of rigid, frictionless side-walls which constrain overall lateral displacements. The whole deflection is divided into some typical columns because of the symmetry. The governing equations of constrained buckling mode and deflection about axial load are deduced, based on linearized differential equation of beam. Point and line contact models are introduced to describe the behavior of the column in constrained buckling process, including load capacity, buckling wave and reaction force. The analysis on the deflection of column is helpful to the research about possible post-buckling paths.

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