7 Vates P, Jones S. Heparin skin necrosis-an important indicator of potentially fatal heparin hypersensitivity.

Flipped classroom depends on the development of information technology and innovative teaching concepts. It reverses time and space of teaching and learning of traditional classroom and induces deep reform of teaching concepts, teaching objectives, teaching methods and interactive mechanism, etc. The thesis puts forward the construction of new teaching model on the basis of having discussed good connection between flipped classroom and CIMA financial operation course. The model is based on basic framework of three design modules of "pre-class-related-post-lecture". It hopes to improve inherent problems of traditional teaching paradigms. It hopes to provide ideas and directions to construct high-effective classroom. It also hopes to promote teaching reform of CIMA course in universities.

Podocytes are highly specialized glomerular epithelial cells that play a crucial role in maintaining the glomerular filtration barrier, impairment of which usually leads to proteinuria. The phenotypic alterations of podocytes are described to be one of the critical mechnisms underlying podocyte detachment from the glomerular basement membrane. High glucose is the major factor mediating the renal damages and podocyte injuries in the process of diabetic nephropathy. It was revealed that high glucose stimulated the epithelial‐to‐mesenchymal transition of podocyte, thus contributing to proteinuria. When the podocytes converse from epithelial phenotype to mesenchymal phenotype, their migratory capacity significantly increases. Previously, cell migration is conventionally detected by the wound healing assay and the transwell assay. In this study, we investigated and comfirmed the possibility of using single cell motility assay for the anaysis of podocyte motility under high glucose condtition.

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