Background: To investigate the effectiveness of the GnRH-a ultra-long protocol, GnRH-a long protocol, and GnRH-a short protocol used in in vitro fertilization-embryo transfer (IVF-ET) in infertile women with endometriosis.

Perceived social support is positively related to life satisfaction in infertile women. Whereas, the underlying mechanism of this relationship is unclear. The present study aimed to investigate whether self-compassion mediated the relationship of perceived social support with life satisfaction and whether infertility self-efficacy moderated the relationship between perceived social support and self-compassion in infertile women. A total of 290 infertile women in mainland China undergoing treatment completed an online survey assessing perceived social support, life satisfaction, self-compassion, and infertility self-efficacy. The results supported the mediation model that perceived social support was associated with life satisfaction via self-compassion. Besides, infertility self-efficacy moderated the relationship between perceived social support and self-compassion. Specifically, perceived social support displayed a stronger predictive effect on self-compassion when infertile women had higher level of infertility self-efficacy.

Objective: This study aims to investigate the influence of Kuntai capsules on the expression level of leukemia inhibitory factor (LIF), insulin-like growth factor-I (IGF-1) and epidermal growth factor (EGF) during the mouse's implantation window of superovulation period and controlled ovarian hyperstimulation period. Methods: A total of 90 female mice were randomly divided into six groups (n=15, each group).The RNA expression of EGF, LIF and IGF-1 in the endometrium on the 4 th day of pregnancy was detected using the fluorescence quantitative PCR method, and the relative expression of these three factors in each group was compared. Results: The mRNA expression of these three factors in the endometrium during the mouse's implantation window period was significantly lower in the superovulation group and COH group than in the control group (P<0.001), and was obviously lower in the superovulation group than in the COH group (P<0.05). The mRNA expression of these three factors in the endometrium remained obviously lower in the superovulation plus kuntai capsule group and COH plus kuntai capsule group, compared with the control group (P<0.01). The mRNA expression of these three factors in the endometrium was lower in control group than in the NS plus kuntai capsule group (P<0.05). Furthermore, the expression in the superovulation and COH groups was lower than in the COH plus kuntai capsule group (P<0.05). Conclusions:Both the superovulation and COH procedure could reduce the mouse's endometrial receptivity. The application of the Chinese medicine Kuntai capsule could partially improve a mouse's endometrial receptivity through the increasing expression of three relevant cytokines during the implantation window.

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