A series of 2-ethoxycarbonylthieno[2,3-b]quinolines were synthesized in the bio-derived “green” solvent γ-valerolactone and evaluated for their inhibitory activities against PTP1B, compound 6a displayed an IC50 value of 8.04 ± 0.71 μM with 4.34-fold preference over TCPTP.
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