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The study shows that TLJNI is capable of preventing the damage of CMECs from both ischemia and ischemia/reperfusion states. Chinese drug can restrain the brain ischemia and ischemia/reperfusion damage by the media that CMECs modulate the neurons, demonstrating the pharmacological mechanisms of TLJNI. This work also indicates that there exist some active substances against ischemia/reperfusion injury secreted from CMECs-CM with TLJNI treatment.

BackgroundThe potential roles of affective responses to environmental stressors in individuals’ physical and mental health are complex and multi-faceted. This study, then, explores Chinese citizens’ emotional responses to COVID-19-related stressors and influence factors which may boost or buffer such effects.MethodsFrom late March to early June (2020), a cross-sectional study was conducted using an anonymous online questionnaire included demographic characteristics, COVID-19-related stressors related to individuals’ daily functioning, and the self-assessed impact of protective and adverse internal factors on emotions.Results1,662 questionnaires were received from residents in 32 Chinese provinces classified by prevalence level according to COVID-19 infections. Among the 17 positive and negative emotional responses, agglomerative hierarchical clustering revealed four subclassifications: (1) stress relations; (2) missing someone relations; (3) individual relations; and (4) social relations. Additionally, heightened regional prevalence levels positively corresponded to intensity of stress relations. Lowest intensity of social relations was found in the areas surrounding Wuhan and coastal areas. Specially, economic- and work-related stressors as well as negative self-perceptions (e.g., suppression, emotionally unstable, self-denial) implicated in negative emotions. While positive emotions were tied to demographic characteristics (e.g., high education, young age and male) and protective traits (e.g., creativity, sympathy, social responsibility), and inversely linked to relationships- and pandemic-related stressors, etc.ConclusionAssociations were clearly noted among Chinese residents’ emotions to specific stressors during pandemic. Providing appropriate psychological resources/supports during future or extended public health crises may help offset the cognitive burden of individuals striving to regain an adequate level of normalcy and emotional well-being.