Background There is a need for an imaging‐based tool for measuring vascular endothelial growth factor (VEGF) expression and overall survival (OS) in patients with glioma. Purpose To assess the correlation between cerebral blood flow (CBF), measured by 3D pseudo‐continuous arterial spin‐labeling (3D‐ASL), and VEGF expression in gliomas on the basis of coregistered localized biopsy, and investigate whether CBF correlated with survival month (SM) in glioma patients. Study Type Prospective cohort. Subjects Thirty‐seven patients with gliomas from whom 63 biopsy specimens were obtained. Sequence 3D‐ASL acquired with a 3.0T MR unit. Assessment Biopsy specimens were grouped as high‐grade (HGG) or low‐grade glioma (LGG). CBF measurements were spatially matched with VEGF expression by coregistered localized biopsies, and the CBF value was correlated with quantitative VEGF expression for each specimen. Patients' survival information was derived and connected with CBF. Statistical Tests Patients' OS was analyzed by Kaplan–Meier and Cox‐regression methods. VEGF expression and CBF were compared in both LGG and HGG. The Spearman rank correlation was calculated for CBF and VEGF expression, SM. Significance level, P < 0.05. Results CBF‐derived 3D‐ASL positively correlated significantly with VEGF expression in both LGG (31 specimens) and HGG (32 specimens), r = 0.604 (P < 0.001) and r = 0.665 (P < 0.001), respectively. LGG and HGG together gave a correlation coefficient r = 0.728 (P < 0.001). Median survival for LGG and HGG patients was 34.19 and 17.17 months, respectively (P = 0.037); CBF value negatively correlated significantly with SM with r = –0.714 (P < 0.001) regardless of glioma grade. CBF was an independent risk factor for OS with HR = 1.027 (P = 0.044), 1.028 (P = 0.010) for univariate/multivariate regression analysis. Data Conclusion CBF determined by 3D‐ASL correlates with VEGF expression in glioma and is an independent risk factor for OS in these patients. Level of Evidence: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:209–220.

There were significant differences in kurtosis parameters (MK and K// ) between HGGs and PCNSLs, while differences in diffusion parameters between them did not reach significance; hence, better separation was achieved with these parameters than with conventional diffusion imaging parameters. J. Magn. Reson. Imaging 2016;44:30-40.

ASL can be a useful noninvasive perfusion MR method for quantitative evaluation of the MVD of brain gliomas.

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