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Background: Currently, the role of interleukin-10 (IL-10) as an anti-inflammatory factor in the occurrence and development of heart disease is still unclear. This study aimed to observe the dynamic changes in the expression of IL-10 in serum and myocardial tissues and to investigate the relationship of IL-10 expression with macrophage activation and cardiomyocyte apoptosis during the occurrence of myocardial infarction (MI).Methods: Mice models with MI were prepared by ligating the anterior descending branch of the coronary artery. The animals were classified into the sham operation group (the control group), and the day 1, 7, 14, and 28 MI groups based.Results: On days 7 and 14, the cells with positive IL-10 expression were largely distributed in the infarct areas, while cells with positive IL-10 expression were decreased on day 28. Serum IL-10 was significantly positively correlated with IL-10 protein expression in myocardial tissues. Moreover, Bcl-2 and Bax protein expression in myocardial tissues, along with the ratio of Bcl-2/Bax proteins, were gradually elevated with prolonged time of infarction. The expression of arginase protein increased gradually too. There were positive correlations between IL-10 and arginase expressions, and between the expressions of Bcl-2 and Bax proteins.Conclusions: After the occurrence of MI, the expression of IL-10 first increased and then decreased in serum and myocardial tissues, with this likely affecting macrophage activation, phenotypic transformation, and the occurrence of cardiomyocyte apoptosis.

The article compares the two distribution automation systems built 10 years before with now in Jinan Power Supply Company . The old distribution automation system put into operation in July 2002, named iES-DMSI000. From the actual use and maintenance of this system, we summarize the problems of this system. Learn from the experience and lessons of the old distribution network systems, we state the construction of the intelligent distribution automation system building in Jinan Power Supply Company now. Breaking the previous systems' construction of island, it can come true that many related information systems can interconnect with each other in the new distribution system. That is the innovation for Control Integration, connecting the various systems with the new distribution automation system, In the end of this article, we abstract the characteristics and experiences of the distribution automation system building in the Jinan Power Supply Company now. And we set up the experience and recommendations of the system setup and maintenance.

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