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Objective: To investigate the diagnostic value of ERCP combined with CRP, CEA and IL-6 in serum in Occult Common bile duct stones (CBDS). Methods: 80 cases of patients with occult CBDS treated in our hospital were selected as the research subjects, and the diagnosis rates of ERCP alone or ERCP combined with CRP, CEA and IL-6 in serum were compared. Results: Versus ERCP alone, the diagnosis rate of combined diagnosis was clearly higher (P < 0.05). Versus patients without CBDS, the levels of CRP, CEA and IL-6 in serum in CBDS patients were apparently elevated (P < 0.05). The levels of CRP, CEA and IL-6 in serum were of high value in the diagnosis of CBDS in patients with occult CBDS (P < 0.05). Conclusion: ERCP combined with CRP, CEA and IL-6 in serum is of high value in re-diagnosis of Occult CBDS.