Cimicifugae Rhizoma (sheng ma) is a well-known traditional Chinese medicine, which has been demonstrated to possess anti-inflammatory, antipyretic and analgesic activities. In the present study, a simple and efficient HPLC-DAD (high-performance liquid chromatography coupled with diode array detection) method was developed and validated for simultaneous quantification of 19 chemical components (including 16 phenolic acids, one coumarin and two alkaloids) in Cimicifugae Rhizoma. The result indicated that this method could effectively evaluate the quality of Cimicifugae Rhizoma and provide a valuable reference for further study. Additionally, the antioxidant activity of Cimicifugae Rhizoma was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl) radical scavenging assay. The results showed that the content of phenolic acids and antioxidant activity exhibited significant correlation coefficients.

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Two new triterpenoid saponins (1-2), with eleven known compounds (3-13) were obtained from ethyl acetate extracts of Anemone tomentosa (Maxim.) Pei by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. The cytotoxic activity of all isolated saponins was evaluated on MDA-MB-231 and PC-3 cell lines.Compounds 5 and 7 showed significant cytotoxicity against with MDA-MB-231 cell and PC-3 cell with IC 50 values of 3. 73-4.21 μM and 3.53-5.37 μM, respectively.

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Two new dammarane-type ginsenosides elucidated as 6-O-[α-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl]-dammar-24-ene-3β, 6α, 12β, 20S-tetraol, named 20(S)-Ginsenoside Re 10 (4); 6-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-[α-D-glucopyranosyl-(1→4)-β-D-glu copyranosyl]-dammar-24-ene-3β, 6α, 12β, 20R-tetraol, named 20(R)-Ginsenoside Re 11 (8); along with one steroidal saponin (1) and six known triterpenoid ginsenosides (2, 3, 5, 6, 7 and 9) were isolated from the radix and rhizomes of mountain-cultivated ginseng (Panax ginseng C. A. Meyer, family Araliaceae). Their structures were determined by comprehensive chemical and spectroscopic analysis. In addition, what's even more concerning is that protodioscin was isolated for the first time from Panax ginseng.