Pattern recognition receptors (PRRs) and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary defense mechanisms against pathogens. Here, we review the major PRR signaling pathways in the zebrafish innate immune system and compare these signaling pathways in zebrafish and humans to reveal their evolutionary relationship and better understand their innate immune defense mechanisms.

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This paper presents a detailed investigation of out-of-round electric locomotive wheels through extensive measurement conducted at field sites. More than 2000 wheels, of seven types of locomotives widely used in China, have been measured since April 2013. The measurement results indicate that two types of freight traffic locomotives suffer serious polygonal wear problems with center wavelengths ranging from 160 to 315 mm. The dominating wavelength is 200 mm. Therefore, the investigations are mainly focused on the two locomotive types. The other types, which are taken for comparison, do not exhibit obvious polygonal wear. However, they exhibited more or less eccentricity. The effect of wheel re-profiling on the wheel polygon is also investigated and discussed. The dominating harmonic orders and center wavelengths after re-profiling are consistent with those before re-profiling at the correct circumstances, if the center wavelength of the polygonal wear is about 200 mm.

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