Green fluorescent CDs using the natural product dandelion as a carbon source were covalently conjugated with folate to differentiate cancer cells from normal cells.

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p27 is an atypical tumor suppressor that can regulate the activity of cyclin-dependent kinases and G 0 -to-S phase transitions. More recent studies reveal that p27 may also exhibit its tumor-suppressive function through regulating many other essential cellular events. However, the molecular mechanisms underlying these anticancer effects of p27 are largely unknown. In this study, we found that depletion of p27 expression by either gene knock-out or knockdown approaches resulted in up-regulation of both Hsp27 and Hsp70 expression at mRNA-and promoter-derived transcription as well as protein levels upon arsenite exposure, indicating that p27 provides a negative signal for regulating the expression of Hsp27 and Hsp70. Consistently

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