An inexpensive and efficient catalyst system has been developed for the N-arylation of nitrogen-containing compounds including a variety of amines, amides, indole and imidazole. This simple protocol uses CuI as the catalyst, commercial available pipecolinic acid as the new ligand, K 2 CO 3 as the base and DMF as the solvent.

It is found that a number of amines, amides, and N-heterocycles undergo efficient N-arylation in the presence of CuI and pipecolinic acid. -(GUO, X.; RAO, H.; FU*, H.; JIANG, Y.; ZHAO, Y.; Adv.