A mild method is described for the conversion of carboxylic acids into esters, amides, as well as peptides without racemization through carboxyl activation by the reagent combination of POCl3 and DMAP.
The reactions described provide a facile and efficient access to cycloalkenyl phosphonates with good to excellent yields via Diels–Alder cycloadditions between alkynyl phosphonates and 1,3-dienes under catalyst-free conditions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.