Actinomycotic liver abscess was diagnosed in a 35-year-old alcoholic farmer from southern India with tender hepatomegaly and fever. CT of the abdomen revealed three coalescing hypodense lesions in the liver. The causative organism could be demonstrated on direct microscopy and cultured from the pus. Treatment with i.v. penicillin for 2 months and oral ampicillin for 5 months resulted in cure as evidenced by clinical improvement and radiological disappearance of the lesions.