Polyketides and nonribosomal peptides are two important classes of natural products that are produced by many species of bacteria and fungi, but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produced in the CAN neurons and promotes survival during starvation-induced larval arrest. Our results uncover a novel mechanism by which animals respond to nutrient fluctuations to extend survival.

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The anionic copper selenolate complex [Me4N]2[Cu4(SePh)6] reacted with CS2 in solvents CH3CN/CH3OH or DMF/CH3OH producing an uncharged two-dimensional layer polymeric complex [Cu(S2COMe)]n(I) and a mononuclear complex [Cu(S2CNMe2)2] (II), respectively. The crystal structure of (I) is reported.

Source of materialIn a typical synthesis, freshly prepared precipitate Cd(OH)2, which was obtained from 1.0 ml (1.0 M) NaOH and a stirred aqueous solution of CdCh · 6H2O (0.291 g, 1.0 mmol) in 5 ml