A simple analytical technique, using a silieic acid minicolumn and capillary gas chromatography, was used for measuring the oxidative interactions of cholesterol vr other compounds. When triacylglycerols were added to cholesterol before heating at 1800C, the latter oxidized faster than cholesterol heated alone, and a relatively high amount of epoxides was found.Dipalmitoylphosphatidylethanolamine and all the amino acids tested showed a protective effect, with cysteine and alanine being the most effective. The results of this study indicate that the varius compounds added not only influenced the rate of cholesterol oxidation, but also exerted different influences on its oxidative pathway.

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An efficient method to directly catalyze asymmetric para C−H aminoalkylation of aniline derivatives to prepare chiral diarylmethylamine system was developed. Aniline derivatives underwent an enantioselective aminoalkylation within the presence of chiral phosphoric acid, affording a series of optically active diarylmethylamine products in good yields and enantioselectivities (73% yield, 91% ee). Furthermore, this method could be used to prepare the key intermediate of chiral drug levocetirizine.