Phenotype clustering of childhood asthma can be helpful to identify clinically relevant patients and reveal different inflammatory characteristics in asthmatic children. Neutrophil-predominant asthma is the most severe asthma phenotype with poor corticosteroid response. Gene expression profile of different asthma phenotypes not only improve our knowledge of childhood asthma, but also can guide asthma precision medicine.

Gene expression profiling of PBMC is useful for the identification of T 1/T 17-mediated asthma with poor treatment control. PBMC and CD8 T cells could be important targets for the investigation and identification of severe asthma.