The article is devoted to the generalization and systematization of theoretical, methodological and practical aspects of assessing the economic security of a regional intersectoral complex. The object of the study is the forest sector as a set of traditional industries and types of economic activity of a separate Russian region united by consistent technological, production, and financial links in the use and reproduction of forest resources. The theoretical and methodological basis of the study was the analysis of scientific works of Russian and foreign scientists devoted to the study of economic security and methodological support for its assessment, modeling of the forest sector, and forest management. The research used methods of multidimensional comparative analysis, as well as traditional methods of processing statistical information. The result of the study is the development of a methodology for rating the economic security of a regional industrial complex and its practical testing in relation to the forest sector of the economy of the subjects of the Ural Federal District. The proposed methodology is universal and, provided that the key provisions are preserved, can be used to assess the economic security of other socio-economic systems.