Gadoxetate disodium is a new liver-specific MR imaging contrast agent. Gadoxetate disodium-enhanced MRI helps the assessment of patients with liver disease. It showed high diagnostic accuracy for the detection of hepatocellular carcinoma.

The KOTO (K 0 at Tokai) experiment aims to observe the CP-violating rare decay K L → π 0 ν ν by using a long-lived neutral-kaon beam produced by the 30 GeV proton beam at the Japan Proton Accelerator Research Complex. The K L flux is an essential parameter for the measurement of the branching fraction. Three K L neutral decay modes, K L → 3π 0 , K L → 2π 0 , and K L → 2γ were used to measure the K L flux in the beam line in the 2013 KOTO engineering run. A Monte Carlo simulation was used to estimate the detector acceptance for these decays. Agreement was found between the simulation model and the experimental data, and the remaining systematic uncertainty was estimated at the 1.4% level. The K L flux was measured as (4.183 ± 0.017 stat. ± 0.059 sys. ) × 10 7 K L per 2 × 10 14 protons on a 66-mm-long Au target.

TACE is more likely to induce HAD in cirrhotic patients with impaired liver function and when a high dose of the chemotherapeutic agent was used.

Purpose:To prospectively compare magnetic resonance imaging (MRI) at 3.0 T and 1.5 T in the same patients for preoperative evaluation of endometrial carcinoma. Materials and Methods:Thirty consecutive patients with endometrial carcinoma underwent MRI at both 3.0 T and 1.5 T as well as surgery. Quantitative and qualitative analyses were performed. Two radiologists independently evaluated images. MR findings were compared with surgicopathologic findings.Results: Image homogeneity of T2-weighted images at 3.0 T was significantly inferior to that at 1.5 T (P ϭ 0.007). The scores of image homogeneity and susceptibility artifacts were not significantly different between 3.0 T gadoliniumenhanced imaging and 1.5 T imaging (P ϭ 0.09 and 0.36). Kappa statistics showed good interobserver agreement between the two radiologists for local-regional staging on T2-weighted images ( Ͼ0.6). The area under the receiver operating characteristic curve (Az) values for T2-weighted imaging in terms of myometrial invasion, cervical invasion, and lymph node metastases were 0.88 (3.0 T) versus 0.91 (1.5 T), 0.84 versus 0.83, and 0.94 versus 0.95 for reader 1, respectively. There were no significant differences between imaging at 3.0 T and at 1.5 T in Az values for either reader (P Ͼ 0.35).Conclusion: 3.0 T MRI is an equivalent imaging modality to 1.5 T imaging for presurgical evaluation of endometrial carcinoma, although not significantly superior to 1.5 T imaging.

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