Papaya (Carica papaya L.) is one of the most important fruits of tropical and subtropical regions of the world. It is believed to be native of Tropical America; probably Southern Mexico from where it spread to most of the Caribbean and Asian countries during the16 th century. India stands first in the production of papaya in the world followed by Nigeria, Indonesia, Mexico, Ethiopia and others. The fruit has high nutritive and medicinal value especially vitamin A (2020 IU/l00g). It also possesses vitamin B, folate and pantothenic acid besides minerals like potassium and magnesium. Five papaya varieties were evaluated for yield and quality parameters under rayalseema dry zone of Andhra Pradesh. The highest yield per plant (45.57 kg) was recorded in TFCP-2 while highest estimated yield per hectare (121.62t/ha) was recorded in the variety Red Lady. Maximum fruit length (21.80 cm), maximum level of total soluble solids (14.88 0 brix) was found in the variety TFCP-4. However, Highest pulp thickness (3.96 cm) was recorded in the variety Red Lady. Among five papaya varieties Red lady was found to be superior in terms of yield and quality parameters.