Two series of novel bis(indole) analogues viz., N 0 -((5-substituted-1H-indol-3-yl)methylene)-n-(1H-indol-3-yl)alkanehydrazides (7a-f) and N 0 -((5-substituted-1-(3-methylbut-2-e nyl)-1H-indol-3-yl)methylene)-n-(1H-indol-3-yl)acetohydrazide (8a-f) were synthesized and characterized by spectral analysis. The target molecules were screened for their antimicrobial, anticancer activities and structure and activity relationship (SAR) was investigated. Compounds 7a, 7c and 8a were found to be active in antimicrobial screening. Anticancer screening reveals that Compound 7c was active against HeLa cell line with an IC 50 of 43.1 lM and compound 7d was found to be interesting candidate with an IC 50 of 26.0 and 30.2 lM against Colo-205 and Hep G2 cell lines respectively. ª 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

A series of novel N-1 and C-3 substituted indole derivatives (5a-f) were designed, synthesized and evaluated for their cytotoxic properties, viz Brine Shrimp Lethality Bioassay (BSLB) besides 5-Lipoxygenase (5-LOX) inhibitory activities through in vitro assays. Structure Activity Relation (SAR) studies showed that compound 5d with an LC 50 of 6.49 lM and 5c with an IC 50 of 33.69 lM were found to be interesting for cytotoxicity and 5-LOX inhibitory activity respectively. ª 2015 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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