Цукровий діабет (ЦД) -системне гетерогенне захворювання, зумовлене абсолютним або віднос-ним дефіцитом інсуліну, який спочатку призводить до порушень вуглеводного обміну, а потім -усіх ви-дів обміну речовин і зрештою спричинює ураження всіх функціональних систем організму. Коморбід-ність ЦД та есенціальної артеріальної гіпертензії (АГ) зумовлює ранній розвиток атеросклеротичного ураження судин, у тому числі коронарних і цере-бральних, з формуванням ішемічної хвороби серця (ІХС), розвитком інфаркту міокарда (включаючи його фатальні варіанти) та інсульту [2,3,5].Сучасні літературні дані свідчать про те, що для всіх вказаних захворювань характерним є ураження судинної системи, особливо на рівні мікроциркуля-ції [1,6]. Однак питання про внесок кожного захво-рювання в сукупність серцево-судинних порушень ще залишається не вивченим до кінця, й виявлення найбільш інформативних показників, що характе-ризують тяжкість ураження серця, магістральних та периферичних судин, має велике практичне зна-чення [4].Неінвазивним, високоінформативним і без-печним методом дослідження при захворюваннях серцево-судинної системи (ССС) є ультразвукова Адреса для листування з авторами: Кочуєва М.М.

In the previous stages of research four integrated ultrasound parameters of heart and blood vessels state (factors) were proposed using the method of factor analysis. These factors had been defined as a linear combination of traditional ultrasound fourteen indicators. In the proposed paper the canonical correlations of these factors with three sets of laboratory indicators of oxidative stress, antioxidant defense, carbohydrate metabolism and existence of mutually directed multivariate correlations between them had been studied. The violation of carbohydrate metabolism was an integral part of the heart and vascular remodeling in patients with arterial hypertension associated with type 2 diabetes mellitus. To improve the diagnostic of antioxidant defense the definition the total antioxidant activity of red blood cells is advisable. Pathogenetically reasonable use of medicines with antioxidant properties was grounded.

The aim: Identification of new, non-trivial knowledge on the prediction of thyroid recurrence on the basis of follow-up data from medical histories. Materials and methods: The development of long-term oncological effects was studied on the catamnestic data of 157 patients diagnosed with thyroid cancer who were treated according to a standard scheme, including radical surgery, radioiodine therapy and hormone therapy. Results: It is shown that the specificity of thyroglobulin as a cancer marker for thyroid cancer is not an unambiguous question and the probability of obtaining false-positive results on its basis is quite significant. It is shown that violation of the recommended terms for special treatment (surgical and radioiodine therapy) can be used as a factor in the prognosis of relapse, and patients who received special treatment with violation of the terms for various reasons require careful attention and more careful examination. The dose of thyroxine that should be used to achieve suppression can be used as a marker of thyroid relapse: an excess of thyroxine levels of 2.8 μg / kg is an indicator of the risk of relapse in the future. Statistically there was no significant effect on the prevention of long-term oncological complications by prolonging the duration of suppressive hormone therapy as a component of thyroid cancer treatment, but there are grounds to believe that prolonged suppression leads to increased cardiovascular and female genital complications. Conclusions: the use of modern information technologies in relation to the arrays of catamnestic data of medical histories allowed to obtain additional knowledge to prevent the development of distant oncological complications resulting from thyroid cancer.

Objective. Evaluate the potential long-term effects of differentiated thyroid cancer (DTC) treatment, on the gastro-intestinal tract (GIT) based on a retrospective study of DTC patients. Methods. Occurrence of long-term GIT pathologies was retrospectively studied in 157 DTC patients. All patients were treated according to the standard of care, which includes radical surgery, radiation therapy and hormone therapy. The database contained digitalised medical histories of patients followed for at least 1 year after treatment. A total of 463 entries were available, representing one entry per noted consequence for each of the 157 patients. The study focused on two aspects. The frequencies of complications before and after treatment were compared, and factors impacting DTC pathology in a statistically significant manner were isolated. Results: The total onset frequency of gallbladder, liver and pancreas disorders was increased by a factor of 1.6 in a statistically significant manner in DTC patients. Patients initially presenting gallbladder disorders received shorter cures of hormone therapy (4 versus 13 months), and lower levels of L-thyroxine in a context of uncompensated hypothyroidism (2.3 versus 3.5 mg/kg). A statistically significant relation was established between the total duration of breastfeeding in women presenting metabolic health disorders, and onset of liver pathology (essentially non-alcoholic steatohepatitis). Conclusion. Life-long GIT pathology monitoring should be standard of care for patients after special DTC treatment. What this paper adds The long-term effects of treatment of differentiated thyroid cancer on the gastro-intestinal tract have never been described to date. Here, a 1.6-fold increase in disorders implicating mainly the gallbladder, liver and pancreas is noted. Gallbladder disorders are shown to be frequent in patients undergoing short courses of thyroid hormone suppression therapy with low levels of L-thyroxine and presenting uncompensated hypothyroidism. In women presenting metabolic disorders, a relation has been established between the total duration of breastfeeding and the later development of liver pathologies.