A kind of active vibration control method was presented through optimal design of driving load of multibody system with quick startup and brake. Dynamical equation of multi-body system with quick startup and brake was built, and mathematical model of representing vibration control was also set up according to the moving process from startup to brake. Then optimization vibration control model of system driving load was founded by applying theory of optimization control, which takes rigid body moving variable of braking moment as the known condition, and vibration control equation of multi-body system with quick startup and brake was converted into boundary value problem of differential equation. The transient control algorithm of vibration was put forward, which is the analysis basis for the further research. Theoretical analysis and calculation of numerical examples show that the optimal design method for the multi-body system driving load can decrease the vibration of system with duplication.