In the current investigation, the solubility of fenoprofen as a nonsteroidal anti-inflammatory drug in supercritical CO2 (SC-CO2) is measured by employing a motorized PVT (pressure–volume–temperature) equilibrium cell. The solubility measurements were carried out in temperatures between 308 and 338 K and pressures between 12 and 40 MPa. The measured data reveals that the solubility of fenoprofen (mole fraction) lies between 2.01 × 10–5 and 4.20 × 10–3, depending on the thermodynamic conditions. Besides the experimental measurement of fenoprofen solubility, thermodynamic modeling of solubility using five different density-based semi-empirical correlations was carried out. The models were considered with only three fitting parameters, namely, Mendez-Santiago and Teja (MST), Bartle et al., Kumar and Johnston (K–J), Chrastil, and Garlapati and Madras models. The results revealed that among the examined models, the Bartle et al. model was the most accurate one with the lowest average absolute relative deviation percent (AARD %) of 6.58% for the studied drug, while the K–J model leads to poor prediction with an AARD % of 9.60%.

Organic-inorganic hybrid materials consisting of inorganic materials and organic polymers are a new class of materials, which have received much attention in recent years. In the present investigation, at first, the surface of nano-alumina (Al 2 O 3) was treated with a silane coupling agent of γ-aminopropyltriethoxysilane (KH550), which introduces organic functional groups on the surface of Al 2 O 3 nanoparticles. Then fluorinated polyimide (PI) was synthesized from 4,4-(hexafluoroisopropylidene) diphthalic anhydride and 4,4-diaminodiphenylsulfone. Finally, PI/modified Al 2 O 3 nanocomposite films having 3, 5, 7 and 10% of Al 2 O 3 were successfully prepared by an in situ polymerization reaction through thermal imidization. The obtained nanocomposites were characterized by fourier transform infrared spectroscopy, thermogravimetry analysis, X-ray powder diffraction, UV-Vis spectroscopy, field emission scanning electron microscopy and transmission electron microscopy. The results show that the Al 2 O 3 nanoparticles were dispersed homogeneously in PI matrix. According to thermogravimetry analysis results, the addition of these nanoparticles improved thermal stability of the obtained hybrid materials. Keywords. Al 2 O 3 nanoparticles; γ-aminopropyltriethoxysilane; polyimide nanocomposite; in situ polymerization.

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