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The purpose of this work was to review the current literature evaluating the efficacy of clinical protocols and preservation methods in preventing ventilator-associated pneumonia (VAP), and to examine the data obtained from the studies systematically. Materials and Methods: Articles reached by scanning national and international databases including "Google Scholar", "Pubmed", "Science Direct", "Proquest", "Cochrane"," EBSCOhost", "Clinical Key", "Ovid", "Web of Science", "Google Akademik" between 2012-2017 were included in this review. In this review, articles with publication language Turkish or English, which evaluated the effects of (VAP) preventing protocols and applications on the results, whichwere published in last five years and of which full text was available were collected by using keywords; "VAP prevention", "Prevention of VAP", "Prevent VAP", "VAP prevention", "Prevent VAP", and "Prevention of VAP". A total of 48 studies which met the inclusion criteria constituted the sample of the study. Results: Randomized controlled; prospective, randomized controlled; semi-experimental; pilot, randomized controlled, prospective, cluster randomized controlled, open label; monocentric ÖZ Amaç: Bu çalışmanın amacı, ventilatör ilişki pnömoniyi önlemede klinik protokollerin ve koruyucu önlemlerin etkinliğini değerlendiren mevcut literatürün gözden geçirilmesi ve çalışmalardan elde edilen verilerin sistematik biçimde incelenmesidir.