Istaroxime is a first-in-class agent which acts through inhibition of the sarcolemmal Na + /K + pump and activation of the SERCA2a pump. This study assessed the effects of a 24 h infusion of istaroxime in patients hospitalised for acute heart failure (AHF).

Changzhou is a typical waterside municipality with approximately 2,500 years of history located south of the Yangtze River. It was an agriculturally oriented region but is becoming an industrialized region. Rural green landscaping in this region possesses characteristics of traditional Chinese gardens. This paper presents a methodology for assessing the visual quality of green landscaping in rural residential areas through public perception-based and expert/design approaches. The former approach enables us to rank green landscaping based on a survey of public preference; the latter weighs the contributions of the attributes contained in a photograph to its overall scenic beauty via correlation, regression, and factor analyses. The photographs used in the survey included road greenways, riparian greenways, residential public gardens and green landscaping around houses, with each type of landscape represented by seven photographs. In total, 141 college students and 41 other participants ranked photographs of each landscaping type from highest to lowest preference. The results indicate that the preferences of students are similar to those of the general public. Examples of green landscaping depicted in the "best" four photographs possessed more attractive qualities regarding the variety of vegetation, richness of colors and a selection of human additions compared to those depicted in the "worst" photographs. The perceived visual quality was positively influenced by, in decreasing order of importance, the variety of vegetation, color contrast, the openness of green spaces, the area of vegetation, and positive man-made elements; conversely, it was negatively influenced by the type of topography. Moreover, some suggestions were offered for future rural greening regarding perceived visual beauty.

BackgroundRecent studies indicated that microRNAs (miRNAs, miRs) were important for many biological and pathological processes, and they might be potential biomarkers for cardiovascular diseases. The present study aims to determine the release patterns of miRNAs in cardiac surgery and to analyze the ability of miRs to provide early prediction of perioperative myocardial infarction (PMI) in patients undergoing coronary artery bypass graft (CABG) surgery.Methodology/Principal FindingsThirty on-pump CABG patients were recruited in this study; and miR-499, miR-133a and miR-133b, cardiac troponin I (cTnI) were selected for measurement. Serial plasma samples were collected at seven perioperative time points (preoperatively, and 1, 3, 6, 12, 24, and 48 hours after declamping) and were tested for cTnI and miRs levels. Importantly, miR levels peaked as early as 1–3 hours, whereas cTnI levels peaked at 6 hours after declamping. Peak plasma concentrations of miRs correlated significantly with cTnI (miR-499, r = 0.583, P = 0.001; miR-133a, r = 0.514, P = 0.006; miR-133b, r = 0.437, P = 0.05), indicating the degree of myocardial damage. In addition, 30 off-pump CABG patients were recruited; miR-499 and miR-133a levels were tested, which were significantly lower in off-pump group than in on-pump group. A prospective cohort of CABG patients (n = 120) was recruited to study the predictive power of miRs for PMI. The diagnosis of PMI strictly adhered to the principles of universal definition of myocardial infarction. The data analysis revealed that miR-499 had higher sensitivity and specificity than cTnI, and indicated that miR-499 could be an independent risk factor for PMI.ConclusionOur results demonstrate that circulating miR-499 is a novel, early biomarker for identifying perioperative myocardial infarction in cardiac surgery.

Our aim was to evaluate the incremental predictive value of adding mean platelet volume (MPV) to the Global Registry of Acute Coronary Events (GRACE) risk score. The MPV and GRACE score were determined on admission in 509 consecutive patients with acute coronary syndrome (ACS). Six-month mortality or nonfatal myocardial infarction (MI) was the study end point. Overall, 61 (12%) patients reached the combined end point. Cox multivariate analysis showed that an elevated MPV was an independent predictor of 6-month mortality or MI in patients with ACS. The addition of MPV to the GRACE model improved its global fit and discriminatory capacity. The new model including MPV allowed adequate reclassification of 16% of the patients. In conclusion, the inclusion of MPV into the GRACE risk score could allow improved risk classification, thereby refining risk stratification of patients with ACS.

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