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al. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med. 2005;202(1):47-59. 6. London NR, Tharakan A, Lane AP, Biswal S, Ramanathan M. Nuclear erythroid 2-related factor 2 activation inhibits house dust mite-induced sinonasal epithelial cell barrier dysfunction. Int Forum Allergy Rhinol. 2017;7(5):536-541. 7. Itoh K, Wakabayashi N, Katoh Y, et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999;13(1):76-86. 8. Steelant B, Seys SF, Boeckxstaens G, Akdis CA, Ceuppens JL, Hellings PW. Restoring airway epithelial barrier dysfunction: a new therapeutic challenge in allergic airway disease. Rhinology J. 2016;54(3):195-205. 9. Sussan TE, Gajghate S, Chatterjee S, et al. Nrf2 reduces allergic asthma in mice through enhanced epithelial cytoprotective function.Asthma is defined as a chronic inflammation of the lower airways and can easily result in bronchoconstriction and even dyspnea.Every year, hundreds of million people around the world suffer from asthma and are unable to work or attend school due to their uncontrolled symptoms. 1 Wheezing is an obvious breathing sound that portrays airflow interference between the lungs and the bronchus and is often considered a primary feature of an acute asthma attack, along with coughing, shortness of breath, and chest tightness. Acute exacerbation or asthma attacks using wheezing sounds have been detected by physicians both with and without stethoscopes. Designs for breathing sound monitoring systems and real-time wheeze detection systems have also been reported. 2 Trubel et al used monofrequent forced oscillation to measure oscillatory airway resistance and calculate variability in order to separate asymptomatic children