Tao L. Increased myocardial ischemiareperfusion injury in renal failure involves cardiac adiponectin signal deficiency. Am J Physiol Endocrinol Metab 306: E1055-E1064, 2014. First published March 4, 2014 doi:10.1152/ajpendo.00428.2013.-Plasma levels of adiponectin (APN) are significantly increased in patients with renal dysfunction and are inversely related to the risk of cardiovascular mortality. The present study was designed to determine the role of APN in myocardial ischemia-reperfusion (MI/R) injury in mice with renal failure and delineate the underlying mechanisms. Renal failure was induced by subtotal nephrectomy (SN). Human recombinant globular domain of adiponectin (gAd) or full-length adiponectin (fAd) was administered via intraperitoneal injection once daily for 7 consecutive days after SN, and in vivo MI/R was introduced 3 wk later. Both plasma and urinary levels of APN increased significantly in SN mice. Compared with sham-operated mice, cardiac function was significantly depressed, and myocardial infarct size and apoptosis increased in SN mice following MI/R. The aggravated MI/R injury was further intensified in APN-knockout mice and markedly ameliorated by treatment with gAd but not fAd. Moreover, SN increased myocardial NO metabolites, superoxide, and their cytotoxic reaction product peroxynitrite, upregulated inducible NO synthase expression, and decreased endothelial NOS phosphorylation. In addition, SN mice also exhibited reduced APN receptor-1 (AdipoR1) expression and AMPK activation. All these changes were further amplified in the absence of APN but reversed by gAd treatment. The present study demonstrates that renal dysfunction increases cardiac susceptibility to ischemic-reperfusion injury, which is associated with downregulated APN/AdipoR1/AMPK signaling and increased oxidative/nitrative stress in local myocardium, and provides the first evidence for the protective role of exogenous supplement of gAd on MI/R outcomes in renal failure. adiponectin; renal failure; subtotal nephrectomy; oxidative/nitrative stress CHRONIC KIDNEY DISEASE (CKD) is a major public health problem worldwide that has been repeatedly documented to be associated with increased risk for cardiovascular morbidity and mortality. It has been increasingly apparent that accelerated cardiovascular disease is prevalent in individuals with CKD and has become the leading complication of renal insufficiency. In particular, the incidence of acute myocardial infarction among patients with CKD is more than twice that of patients without CKD (28). Therefore, the prevention and treatment of cardiac insult are critical considerations in the management of individuals with CKD. Adiponectin (APN), a 30-kDa adipocyte-derived vasoactive peptide involved in the regulation of inflammation and energy metabolism, has shown beneficial effects on cardiovascular disorders (11). It is highly abundant in the circulation and exists as trimers, hexamers, or high-molecular-weight multimers (22). Hypoadiponenemia has been observed in individuals with i...

Designed growth of a novel PEDOT/graphene oxide (GO) hybrid and obtained hybrid demonstrates superior electrochromic performance.

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