The sparse group Lasso is a widely used statistical model which encourages the sparsity both on a group and within the group level. In this paper, we develop an efficient augmented Lagrangian method for large-scale non-overlapping sparse group Lasso problems with each subproblem being solved by a superlinearly convergent inexact semismooth Newton method. Theoretically, we prove that, if the penalty parameter is chosen sufficiently large, the augmented Lagrangian method converges globally at an arbitrarily fast linear rate for the primal iterative sequence, the dual infeasibility, and the duality gap of the primal and dual objective functions. Computationally, we derive explicitly the generalized Jacobian of the proximal mapping associated with the sparse group Lasso regularizer and exploit fully the underlying second order sparsity through the semismooth Newton method. The efficiency and robustness of our proposed algorithm are demonstrated by numerical experiments on both the synthetic and real data sets.

Background: Certain mRNAs are anchored to the endoplasmic reticulum (ER) by p180. Results: The placental alkaline phosphatase mRNA requires its transmembrane domain coding region to be anchored by p180. Conclusion: Translational-independent ER targeting of mRNA by p180 can be mediated by regions of the ORF that encode hydrophobic peptides. Significance: Translational-independent targeting of mRNA to membranes may be mediated by a mechanism conserved between prokaryotes and eukaryotes.

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Background/Aims:Partial splenic embolization (PSE) is used in the management of gastroesophageal variceal hemorrhage (GEVH). However, it is uncertain whether it has beneficial effects for GEVH patients in preventing variceal recurrence and variceal hemorrhage, as well as promoting overall survival (OS), when it is combined with conventional therapies.Materials and Methods:The databases including PubMed, EMBASE, Web of Science, Google scholar, and Cochrane Central Register of Controlled Trials were searched up to 11th of November, 2015. Meta-analyses were performed by using Review Manager 5.3 software for analyzing the risk of bias, Newcastle-Ottawa Scale for assessing the bias of cohort studies, and GRADEprofiler software for assessing outcomes obtained from the meta-analyses.Results:A total of 1505 articles were reviewed, and 1 randomized controlled trial and 5 cohort studies with 244 participants were eligible for inclusion. The pooled hazard ratio (HR) of variceal recurrence is 0.50 (95% confidence interval (CI) 0.37, 0.68; P< 0.00001; I2 = 0%). The pooled HR of variceal hemorrhage is 0.24 (95% CI 0.15, 0.39; P< 0.00001; I2 = 0%). The pooled HR of OS is 0.50 (95% CI 0.33, 0.67; P< 0.00001; I2 = 0%). Meta-analyses demonstrated statistically significant superiority of combinational therapies over conventional therapies in preventing variceal recurrence and variceal hemorrhage and prolonging OS. The complications related to PSE were mild or moderate and nonfatal.Conclusions:The results indicate that PSE has beneficial effects for GEVH patients, however, future investigation with a larger number of subjects in clinical trials is warranted.

This article analyses the non-market value of cultivated land resources firstly, then makes a further study why the
cultivated land resources lack of non-market value compensation under current land expropriation systems. The
results prove that vacancy of non-market value not only does harm to rights of farmers, but also makes the loss
of total social welfare and results in disorder circulation during non-agricultural. Finally, this paper tries to
improve and perfect current compensation systems of land expropriation based on non-market value category.