Pre-mRNA processing factor 19 (PRPF19) is a multifaceted protein and participates in DNA damage response and pre-mRNA processing. The role of PRPF19 in cancer is unclear. Here, we report that the expression of PRPF19 in human tongue cancer is associated with unfavorable prognosis. Overexpression of PRPF19 promotes while knockdown of PRPF19 inhibits tongue cancer cell migration, proliferation, and tumor growth. Overexpression of PRPF19 increases the resistance of tongue cancer cells to radiation and cisplatin treatment. Furthermore, PRPF19 regulates the expression of solute carrier family 40 member 1 (SLC40A1) and mono-ADP ribosylhydrolase 2 (MACROD2), knockdown of SLC40A1 or MACROD2 decreases the sensitivity of tongue cancer cells to radiation and cisplatin treatment. Thus, our results establish a key role of PRPF19 in tongue cancer growth and chemoradiotherapy resistance, targeting PRPF19 would be an effective therapeutic strategy for tongue cancer, especially for those resistant to chemoradiotherapy.

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Nowadays there are lots of problems with a background in geotechnical engineering that cannot be separated from another important subject, fluid dynamics. Such problems include, for example, leaking problems with ground foundations, turbulent water in groundwater, and so on. This passage organized basic knowledge of two subjects that directly help to understand complex problems and introduced some advanced solutions to solve the problems of these complex problems. Darcy’s Law is the key to working out all the leaking problems under earth because of the low speed and rate of flow. Turbulent water is a hot topic to talk about and there are no such overall equations as Darcy’s Law to understand different problems but it’s possible to combine the half-rational equations and the data of the field survey together and concluded a new formula. To understand more such complex problems, using simulating software is a good choice and there will be more and more topics containing interdisciplinary knowledge in the future.