Urticaria affects ¼ of people at least once in a lifetime. It is a clinical reaction turned by many factors, causing the liberation of vasoactive substances such as kinines, prostaglandins and histamine. Chronic urticaria is classified according its duration to less or more than 6 weeks. Foci of infection in the oral cavity and its relationship with the general health of the patient have been long studied. The oral cavity is considered as intersection of dentistry and medicine and "the window to general health". Infection from the oral cavity may create or aggravate general health.We present a clinical case of a 49-years old female patient with chronic urticaria, presented with the typical multiple urtics located mostly on the lateral surfaces of the abdomen -bilaterally. The major complaint was severe itching and burning sensation on the skin.

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Epstein-Barr virus and Cytomegalovirus have different oral manifestations which could be presented in the oral cavity most commonly as non-specific oral ulcerations and lymphadenopathy. A lot of people acquire primary infection with Cytomegalovirus and if they later become immunosuppressed, such as human immunodeficiency virus (HIV), Cytomegalovirus is likely to become reactivated. We present a clinical case of a young man with multiple painful oral ulcerations with duration more than several years. The patient applied different types of local creams without significant results. After the clinical examination our recommendation was to investigate serum levels of EBV-IgG and CRP-IgG and HIV-1 and-2, complete blood count with differential (CBC), folic acid, CRP. The laboratory results revealed positive IgG antibodies against CMV and EBV, folic acid deficiency.

Osteoarthritis is a degenerative joint disease, affecting approximately 27 million Americans. It can affect any joint, but it occurs most often in knees, hips, lower back and neck, small joints of the fingers and the bases of the thumb and big toe. We present a 53 years-old woman with chronic OA of the small joints of the fingers with complaints of pain, swollen and warmed joints of the left and right hands. The patient was referred to the Department of Oral Imaging and Oral Diagnostics to perform a consultation due to elevated levels of CRP and ESR. The patient underwent focal dental diagnostic protocol. We remarked an active dental focustooth 46. It was retreated endodontically under antibiotic protection and the patient was followed-up after one month with decreased levels of CRP and ESR.

Osteoarthritis is a degenerative joint disease, affecting approximately 27 million Americans. It can affect any joint, but it occurs most often in knees, hips, lower back and neck, small joints of the fingers and the bases of the thumb and big toe. We present a 53 years-old woman with chronic OA of the small joints of the fingers with complaints of pain, swollen and warmed joints of the left and right hands. The patient was referred to the Department of Oral Imaging and Oral Diagnostics to perform a consultation due to elevated levels of CRP and ESR. The patient underwent focal dental diagnostic protocol. We remarked an active dental focustooth 46. It was retreated endodontically under antibiotic protection and the patient was followed-up after one month with decreased levels of CRP and ESR.