No abstract

Introduction: Typhae pollen (TP) has been used as an anticoagulant in traditional Chinese medicine and throughout Asia. Typhae Pollen Carbonisata (TPC), a processed product of TP, has hemostatic properties. TPC is produced by frying TP, and the degree of processing can be judged by the colour change from yellow to brown. Objective: To establish a novel method for quality assessment of TPC and discriminate TPC from underdone products and overdone products. Methodology: The Commission Internationale de l'Eclairage (CIE) L * a * b * colour space values of TP and TPC were measured to establish the colour model of TPC. Ultra-performance liquid chromatography was developed for fingerprinting. Thrombin activity promoting rates, clotting time, and bleeding time illustrated the difference in the hemostatic effect of the processed products. Chemometric approaches were performed to reveal the correlation between components and colour values or thrombin activity. Results: Reference ranges of colour values and mathematical functions of TPC were established. The developed method was found to be fast, economic, sensitive, and stable. Fingerprints and thrombin activity in conjunction with partial least squares (PLS) demonstrated that peaks 2, 4, 7, 30, and 36 (isorhamnetin) were the main contributors for colour values and hemostatic activity of TPC. Conclusions: TPC and its unqualified products can be effectively distinguished based on chromaticity analysis, which provides a powerful tool for the comprehensive evaluation of the quality of Chinese herbal medicines.

A total of 22 phase I metabolites of pimavanserin were detected and tentatively identified. This report presents the first study of screening and identification of the metabolites of pimavanserin. The UHPLC/FT-ICR-MS method is a powerful tool for exploring and identifying metabolites in complex biological samples.

It is extremely important to cultivate talents with both political and moral integrity, highlighting the importance of ideological and political education in the course of talent training in universities. The course of professional introduction is the first professional basic course for freshmen, which has a great impact on students' four years of study, and the ideological and political construction of the course in the professional introduction has a very important role in shaping students' personality and three outlooks. This paper analyzes the construction planning, implementation and evaluation results of the ideological and political construction of the introduction course of electronic information engineering in Xi'an Polytechnic University, and expounds the highlights of the reform of the ideological and political construction of the introduction course of electronic information specialty through the data in the paper, with a view to providing reference for the relevant professional introduction courses in relevant universities.