For application in drug discovery and biomedicine, it is crucial to develop new biocompatible methods to modify polypeptides. Herein, a visible-light-induced photoredox trifluoromethylation of tryptophan-containing peptides is reported. Under a mild, biocompatible, and straightforward condition, this strategy could incorporate the trifluoromethyl group into tryptophan residue with excellent chemo-and site-selectivity. The use of lower photocatalyst loading in 2 mol-% and cheap CF 3 SO 2 Na salt represents a great catalytic activity and [a] Methyl N-Acetyl-S-trifluoromethyl-L-cysteinate (2e): [15a] White solid. 1 H NMR (400 MHz, CDCl 3 ) δ = 6.84 (d, General Procedure for Trifluoromethylation of Di-, Tri-and Tetrapeptides: A solution of peptide 3 (0.20 mmol), CF 3 SO 2 Na (0.40 mmol) and Ir[dF(CF 3 )ppy] 2 (dtbbpy)PF 6 (2 mol-%) in CH 3 CN (2 mL) was stirred under air atmosphere and irradiated by 3 W blue LEDs for 4 h. When the reaction finished, the solvent was removed under reduced pressure by an aspirator. Then, the product was obtained by flash column chromatography on silica gel (dichloromethane/ethyl acetate) to afford corresponding trifluoromethylation of peptide 4. Ac-Trp(CF 3 )-Gly-OMe (4a): [15b] White solid. 1 H NMR (400 MHz, CD 3 CN) δ = 10.18 (s, 1H), 7.76 (d, J = 8.1 Hz, 1H), 7.42 (d, J = 8.2 Hz, ]DMSO) δ = 11.91 (s, 1H), 8.23 (d, J = 7.9 Hz, 1H), 8.05 (d, J = 8.9 Hz, 0.54H) & 7.99 (d, J = 9.0 Hz, 0.12H), 7.83 (d, J = 8.1 Hz, 0.82H) & 7.77 (d, J = 8.3 Hz, 0.15H), 7.41 (d, J = 8.2 Hz, 1H), 7.26 (t, J = 7.6 Hz, 1H), 7.11 (t, J = 7.5 Hz, 1H), 4.75-4.57 (m, 0.88H) & 4.57-4.47 (m, 0.15H), 4.42-4.25 (m, 1H), 3.61 (s, 0.44H) & 3.55 (s, 2.

Objective: To investigate the effect of clinical nursing pathway (CNP) combined with cluster nursing mode in intravenous biologic treatment of rheumatoid immune disease patients. Methods: Convenience sampling method was used to select inpatients receiving biologics treatment in Rheumatology and Immunology Department of a grade A hospital in Jingzhou city from May 2020 to April 2022. 75 patients from May 2020 to April 2021 were selected as the control group, and 75 patients from May 2021 to April 2022 were selected as the observation group. The control group was given routine care. The observation group was treated with CNP combined with cluster nursing mode on the basis of the control group, and the incidences of adverse infusion reactions, total treatment time, patient satisfaction and nurse satisfaction were compared between the two groups. Results: There were statistically significant differences between the two groups after intervention (P < 0.05). Conclusion: Using CNP combined with cluster nursing mode is beneficial to reduce the incidence of adverse infusion reactions in patients, shorten the total treatment time, and improve the satisfaction of patients and nurses.

Objective: To investigate the effect of wax therapy in pain care of patients with rheumatoid arthritis. Methods: Convenience sampling method was used to select inpatients with rheumatoid arthritis admitted to the rheumatology and immunology department of a 3A hospital in Jingzhou City. 75 patients from January 2021 to June 2021 were selected as the control group, and 75 patients from January 2022 to June 2022 were selected as the observation group. The control group was given routine nursing, and the observation group was implemented wax therapy nursing on the basis of the control group. The relief of clinical symptoms (morning stiffness time, pain score) and quality of life score of the two groups were observed. Results: After intervention, there was statistical significance between the two groups (P < 0.05). Conclusion: Wax therapy can improve the time of morning stiffness, the degree of pain and the quality of life of patients with rheumatoid arthritis.

Objective: The paper aims to investigate the clinical nursing pathway (CNP) in the application of immunosorption therapy in patients with rheumatic immune disease. Methods: Convenience sampling method was used to select inpatients who received immunoadsorption therapy from January 2020 to December 2022 in the rheumatology and Immunology department of a 3A hospital in Jingzhou City. 30 patients from January 2020 to June 2021 were selected as control group, and 30 patients from July 2021 to December 2022 were selected as observation group. The control group was given routine nursing. On the basis of the control group, the observation group used a clinical nursing pathway for intervention during the perioperative period of immunosorbent therapy. The incidence of adverse reactions, patient satisfaction, and nurse satisfaction during immunosorbent therapy between the control group and the observation group were compared. Results: After intervention, the incidence of adverse reactions in the observation group was significantly lower than that in the control group, while patient satisfaction and nurse satisfaction in the observation group were significantly higher than those in the control group. The results are all statistically significant (P < 0.05). Conclusion: Clinical nursing pathway is beneficial to reduce the incidence of adverse reactions in patients with immunoadsorption during peri-treatment and improve the satisfaction of patients and nurses.