Background: Controlling host phosphoinositide metabolism is critical in bacterial infection. Results: A Legionella effector, SidP, has been identified as a phosphoinositide phosphatase, and its crystal structure was determined. Conclusion: SidP is a PI(3)P phosphatase, which may play a role in controlling bacterial phagosomal lipid composition. Significance: Identification of a novel PI phosphatase suggests the importance of exploiting host PI lipids in many bacterial infections.

A facile and efficient strategy to synthesize substituted thiazoles via a cascade reaction from chromone derivatives and thioamides in an environmentally benign medium was developed. This cascade reaction involves a...

No abstract

Correction for ‘Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides’ by Tianzi Dai et al., Org. Biomol. Chem., 2020, 18, 6162–6170, DOI: 10.1039/d0ob01019g.