Asian Pac J Cancer Prev, 16 (2), 513-517 IntroductionLung cancer is the leading cause of death of cancer world-wide, causing more than 1 million deaths per year (Jemal et al., 2010). It is a disease characterized by uncontrolled cell growth in tissues of the lung. The global cancer burden in annual cases is projected to double by 2050, and lung cancer is expected to remain the leading cause of all cancer deaths during that time (Brothers et al., 2013). Cigarette smoking remains the main risk factor for lung cancer, with 85%-90% percent of lung cancer cases caused by active or passive smoking. Conventional treatments for lung cancer are surgery, radiotherapy and chemotherapy. And the choice of method depends on the type, progress and relevant genes of lung cancer. Besides, targeted therapy, as a more accurate and specific treatment, has come into our field of vision for us to choose from. It won't cause any harm to adjacent normal lung cells when it uses specific drugs to identify and target cancer cells.Recently, genetic, transcriptomic and epigenomic biomarkers are emerging as tools for the early diagnosis of lung cancer both in the screening setting and diagnostic. Furthermore, epigenetics refers to heritable modifications