Insoluble elastin was rendered soluble by pepsin digestion and HCl treatment. The antioxidative activity of pepsin-solubilized elastin (PSE) and acid-solubilized elastin (ASE) was investigated. The peroxide value and carbonyl value of oleic acid in the presence and absence of PSE and ASE after oxidation at high temperature (75−90 °C) were evaluated. Both PSE and ASE were effective inhibitors of the oxidation of oleic acid. The antioxidative activity of PSE and ASE was enhanced in the presence of citric acid as a synergist. Both PSE and ASE are thought to be valuable as antioxidants. Since the preparation of ASE was easier than the preparation of PSE, ASE could therefore be more useful as an antioxidative agent. The antioxidative activity of low molecular weight peptides obtained from ASE could be found by the ferric thiocyanate method. Keywords: Elastin; antioxidant; antioxidative peptide

The year 2019 ended with the official report of an unknown pneumonia outbreak in Wuhan, Hubei Province, China. Subsequently, this novel pneumonia was named COVID-19, which mainly attacks the respiratory system, causing severe damage. Although vaccination has relieved the stress of combating pandemics around the world after one year, there are still unknowns and challenges that come with hope. In this regard, stem cell therapy has been proposed as an effective approach to treating COVID-19. Mesenchymal stem cells (MSCs) can potentially be used as a hopeful tool in the cell-based therapy due to their ability to regenerate and regulate immune response. Although research and clinical results have shown encouraging achievement in patients who were treated with MSCs, drawbacks and challenges still exist in the face of new opportunities. This review aims to introduce the challenges of the COVID-19 vaccine and the possible clinical use of MSC-based therapy. Through analysis of COVID-19 and MSC-based therapy, the author aims to find the possibilities and feasibility of using MSCs to treat acute respiratory diseases, such as COVID. As a result, the author finds that MSC treatment is very practical, and it shows significant potential to treat COVID-19.

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Three Gorges Project Management System (TGPMS) is a large scale, integrated project management system which is designed for construction management in Three Gorges Project, and it has already been developed to support crossarea, multi-organization applications with the progress of project, and the extending of enterprise business. It is valuable for optimizing the high availability of information system by reviewing the migration road of TGPMS architecture and discussing system high availability design and implementation.

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