This paper investigated the spatial and temporal variations of the Universal Thermal Climate Index (UTCI) of the China-Pakistan Economic Corridor (CPEC) from 1979 to 2018. The European Centre for Medium-Range Weather Forecasts Re-Analysis-Interim (ERA-Interim) reanalysis data from the European Centre for Medium-Range Weather Forecasts (ECMWF) is selected for UTCI calculation in the region and analyzed by a linear trend and correlation analysis. The results showed that (1) the UTCI of CPEC is decreased with the increase of latitude and altitude. There is obvious spatial heterogeneity in the seasonal scale and the spatial distribution of different thermal stress categories. (2) UTCI generally exhibited a positive trend of 0.33 °C/10a over the past 40 years, and the seasonal variation characteristics of UTCI show an upward trend in all four seasons, of which spring is the fastest. On the space scale, the growth trend has significant spatial variations. (3) Temperature has a positive correlation with UTCI. The influence of temperature on UTCI is greater than that of wind speed. The results of this study will be helpful for regional planning and also contribute to comprehending the characteristics of the thermal environment in CPEC.
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