MRI-guided Low Intensity Focused Ultrasound is superior to other minimally invasive neuromodulation procedures in terms of spatial resolution and activating deeper brain areas. Parkinson's, Alzheimer's, essential tremor, brain cancer, epilepsy, nerve block, medicine administration, and stroke benefit from MRI-guided LFUS. This minimally invasive neurostimulation approach is also safe . Future clinical trials should focus on Focused Ultrasound for neurologic diseases. MRI-guided Low Intensity Focused Ultrasound is a new modality for performing incision-less neurosurgical procedures such as thermoablation. According to emerging evidence, low-intensity can also be used for neuromodulation with several advantages, including high spatial precision and targeting deep brain regions. We review the existing data on the biological mechanisms of MRI-guided Focused Ultrasound, neuronal activity emerging indications for neuromodulation, and the strengths and limitations of this approach.