Results: No significant difference was found for patient age (P = .741), sex (P = .900), lesion size (P = .206), or lesion origin (P = .788). Median time was 576 seconds for CT-guided biopsy (25th percentile, 418 seconds; 75th percentile, 714 seconds) and 311 seconds for US-guided biopsy (25th percentile, 152 seconds; 75th percentile, 480 seconds) (P < .001). Post-procedural pneumothorax was observed in 24 of 162 (14.8%) CTguided procedures and in five of 98 (5.1%) US-guided procedures (P = .025); hemorrhage occurred in two of