Original Article optimized formulation (F7), drug solution via nasal route was compared with drug solution administered orally, in rotenone induced male wistar rats. Group treated with optimized pharmacosomes formulation (F7) showed significant recovery in rat weight (43%), locomotor activity by photo actometer (90%) and grip strength on retard (65%) compared to drug solution treated orally showed recovery in rat weight (32%), locomotor activity by photo actometer (57%) and grip strength on rotarod(30%). Biochemical parameters measured in brain homogenate showed significant reduction in induced levels of nitric oxide (82%), total protein (88%) and lipid peroxides (73%) and significant increase in reduced Glutathione (67%). Whereas drug solution treated via orally showed significantly less activity in the reduction of nitric oxide (28%), total protein (59%) and lipid peroxidation (33%) and reduced glutathione (10%).