FindingsThe prevalence of any lifetime psychiatric (non-SUD) disorder was 41.8%, with major depression (17%) and antisocial personality disorder (17%) being the most prevalent disorders. After adjusting for age and study, the odds of having any lifetime non-SUD (OR 2.10; 95%CI Research limitations/implicationsPsychiatric disorders are common among people who use substances, with gender differences reported for specific disorders. Gender-sensitive integrated treatment approaches are required to prevent and to address comorbidity psychiatric disorders among this population. Originality/valueThis secondary analysis of five cross-sectional studies included a large sample size allowing sufficient power to examine differences between men and women.An additional strength of the methodology is the use of the gold standard PRISM which was used to assess disorders.