Background: Formocresol (FC) reported high success rates when used in pulpotomy of primary molars , however many concerns have been raised regarding its mutagenicity, carcinogenicity, its local toxicity, Objectives: to assess the success rates of Antioxidant mix and FC, used as pulpotopmy agents in vital primary molars, both clinically and radiographically. Materials and Methods: Randomized clinical trial. Fifty-two (52) primary mandibular molars in thirtyfive (35) children ranging in age from four to eight years were included in the study. Molars were divided into two equal groups (n= 26), Antioxidant mix (group 1) & FC (group 2) as a pulp medicament. All pulpotomized teeth were finally restored with stainless steel crowns. Subjects were monitored clinically & radiographically at three, six and nine months. Results: The clinical and radiographic success rates of Antioxidant mix & FC by the end of the nine months were [(84.6 & 46.2%) & (88.4 & 84.6%)] respectively. Conclusion: Antioxidant mix may not provide a reliable biological method for vital pulp therapy in primary molars.