Hyperthermia therapy is a promising therapy for liver cancer treatment that utilizes external electromagnetic waves to heat the tumor zone to preferentially kill or minimize cancer cells. Nevertheless, it’s a challenge to realize localized heating of the cancer tissue without harming the surrounding healthy tissue. This research proposes to utilize nanoparticles as microwave absorbers to enhance microwave imaging and achieve localized hyperthermia therapy. A realistic 3D abdomen model has been segmented using 3D Slicer segmentation software, and then the obtained segmented CAD model exported to Computer Simulation Technology (CST STUDIO) for applying the Finite Element Modeling (FEM). Next investigating both imaging and treatment capability. Finally, the specific absorption rate (SAR) and temperature distribution were computed without nanoparticles and with different types of nanoparticles such as gold (GNPs) and silver nanoparticles at frequency 915 MHz. By comparing the achived results, it was seen that Silver nanoparticles can make a great enhancement in raising the temperature. However, this result was unsatisfactory but, after adding gold nanoparticles the temperature exceed 42°C, at frequency 915 MHz which is achieving the hyperthermia treatment without harming the nearby healthy tissue, GNPs also can achieve a great enhancement in SAR result

Chicory ( Cichorium intybus L.) is widely consumed as a food plant in many regions of the world and has been involved in traditional medicine due to its unique contents of phytochemicals. We aimed to investigate the anti-fungal, anti-hemolytic, and anti-cancer activities of chicory roots and leaves ethanolic extracts, and their Chitosan nanoparticles (Chit NPs) formulations. The ethanolic extract of chicory roots and leaves were microencapsulated into Chit NPs. The anti-hemolytic, anti-fungal, and anti-cancer activity of chicory extracts and their Chit-NPs were investigated, along with an in vitro toxicological study. Chicory extracts encapsulation into Chit NPs increased their anti-fungal activity against two fungal pathogens, Candida albicans and Aspergillus flavus. Chicory extracts and their Chit NPs appeared strong anti-hemolytic activity in hypotonic media. Due to microencapsulation of roots and leaves extracts into Chit NPs, the IC50 was decreased 2.49 and 2.6-folds in HepG2 and MCF-7 cell lines, and 6.31 and 5.50-folds in HepG2 and MCF-7 cell lines, respectively. The in vitro toxicological study revealed that the IC50 of chicory roots (56.84 ± 6.4 μg/ml) and leaves (45.51 ± 4.2 μg/ml) decreased 8.45 and 6.77-folds in the normal human fibroblasts (WI38) cell line, compared to Doxorubicin (6.72 ± 0.5 μg/ml). Microencapsulation of extracts into Chit NPs increased their toxicity 2.43-folds for Chit-Roots NPs (IC50 = 23.35 ± 2.3 μg/ml) and 1.22-fold for Chit-Leaves NPs (IC50 = 37.29 ± 2.9 μg/ml). Chicory-Chit NPs possess promising anti-cancer and anti-hemolytic activities. It is worth for further testing their efficacy and toxicity in pre-clinical animal models as well as clinical trials.

I N the present study, the radiation dose and image quality between two techniques, namely; automatic tube current modulation (ATCM) and fixed tube current (FTC), in computed tomography (CT) of multiphasic examination of the liver, were evaluated. For this objective, fifty liver CT patients examined were investigated by arterial, portal, venous, and equilibrium measures following scans of hepatic circulatory phases. All stages, except for tube current, a portal, and a venous phase, have been carried out by the FTC, ATCM and correlated with their dosage and image quality, with similar scanning and reconstruction parameters. In these techniques, the CT unit automatically displays , both the radiation dose measurements and the dose index volume (CTDIvol), simultaneously. Also, for quality insurance, the images obtained were quantitatively evaluated by the contrast noise ratio (CNR).The results showed that the averaged of CTDI vol was 26.07 mGy in FTC, and 13.71 mGy in ATCM. As compared with the FTC technique, CTDI vol was reduced by using the ATCM technique. The average value of CNR were(28.93, 29.98) HU in FTC and ATCM, respectively.

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