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Renal ultrasonography was performed in 45,905 adults, including 41,364 without any signs suggesting urinary tract malignancies, 1,667 with microscopic hematuria only and 2,874 with some signs of malignancy. Renal lesions were found in 355 adults (0.858%) in the asymptomatic, 39 (2.3%) in the microscopic hematuria and 75 (2.6%) in the symptomatic groups, respectively. Renal cell carcinoma was found in 35 (7.5%) lesions: 19 (5.4%) in the asymptomatic, none in the microscopic hematuria and 16 (21.3%) in the symptomatic groups. A total of 47 patients, including 12 other renal cell carcinoma patients transferred from related hospitals, was grouped into 28 without and 19 with symptoms. Primary tumor size and clinical stages were significantly smaller and lower, respectively, in the asymptomatic group than in the symptomatic group. Radical nephrectomy was performed in all but 2 asymptomatic patients. The 5-year survival rates after nephrectomy were 94.7 and 60.9% for the asymptomatic and symptomatic groups, respectively (p less than 0.01). The results indicate that ultrasonography is a useful tool to detect low stage asymptomatic renal cell carcinoma at low cost.

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Thirty-one of 40 patients with gallbladder carcinoma whom we treated from December 1983 through June 1999 underwent resection of cancers extending from the mucosa (m) (pTis-pT1a) to the subserosa (ss) (pT2). The patients were classified into five groups according to the layered-structure of the gallbladder wall and the internal echo of tumors visualized in ultrasound images. Group A included pedunculated polyps with round margins, homogeneous hypoechoic internal echoes, and intact outer hyperechoic layers; group B, broad-based lesions with homogeneous hypoechoic internal echoes and intact outer hyperechoic layers; group C, broad-based lesions with intact outer hyperechoic layers and more heterogeneous hypoechoic internal echoes in their centers than those in the marginal lesions; group D, broad-based lesions with irregularity and/or thinning of outer hyperechoic layers; and group E, tumors that could not be evaluated. The ultrasonograms and histopathologic findings of groups A through D were compared, and the surgical techniques used in each group were examined. Outcomes achieved by groups A through C, with their intact outer hyperechoic layers, were compared with those achieved by groups D and E.The six tumors in group A were all well-differentiated adenocarcinomas confined to the mucosa (pTis), and simple cholecystectomy was considered appropriate. The eight tumors in group B comprised three cases of m (pTis-pT1a) cancer, two cases of cancer invading the muscularis propria (mp) (pT1b), and three cases of cancer minutely scattered in the infiltrating subserosal fibrous layer (ss fibrous layer) (pT2). Accordingly, because of the difficulty of determining depth of invasion, resection of the liver bed was considered appropriate in group B. Histopathologic examination of group C showed that the tumors had invaded the ss fibrous layer (pT2) in all six patients. Although the ss fat layer had not been invaded, metastasis to the lymph nodes of the cystic duct (30%) had occurred, suggesting that a favorable outcome could be expected if the patient underwent resection of the liver bed and lymphadenectomy of the cystic duct, pericholedochal, hilar, peripancreatic, periportal, common hepatic, and proper hepatic lymph nodes. Group D comprised two patients with cancers that had invaded the ss fat layer (pT2). All nine tumors in group E were ss (pT2) cancers. The 5-year survival rate was 100 percent in groups A, B, and C; 50 percent in group D, and 45 percent in group E. Five-year survival rates were significantly lower in groups D and E than in groups A, B, and C, in which the outer hyperechoic layer remained intact (p<0.01).Gallbladder carcinomas with intact outer hyperechoic layers were classified into three groups (groups A, B, and C), in which depth of invasion ranged from m (pTis-pT1a) to the ss fibrous layer (pT2). These three groups were associated with favorable outcomes, although different surgical techniques were required for each group. An intact outer hyperechoic layer in the ultrasonogram is a predictor of a favo...