A new experimental model of chronic pancreatitis was produced by a combination of chronic ischemia and incomplete obstruction of the pancreatic duct. Ischemia was induced by ligation and separation of branches flowing into the left pancreatic lobe from the splenic artery. Incomplete ductal obstruction was achieved by ligation and separation of the minor pancreatic duct and placement of a polyethylene tube in the major pancreatic duct. Macroscopic examination at 6 months after model preparation showed that the pancreas was hard, with severe inflammatory change. In the secretin test, the flow rate of pancreatic juice, amylase output and bicarbonate concentration were significantly reduced as compared with the controls. Pancreatography revealed dilatation and meandering of the major pancreatic duct and poor visualization of its secondary and tertiary bifurcations. The histopathological findings consisted of a decrease in the pancreatic parenchyma, replacement of fat, severe inflammatory cell infiltration, extensive fibrosis and tubular complexes. This model most closely resembles human chronic pancreatitis, and is a very useful instrument.

Interactions of monomer forms of protoporphyrin IX, deuteroporphyrin IX, hematoporphyrin IX, and coproporphyrin III, respectively, with α- and γ-cyclodextrin in 0.002 mol·dm−3 NaOH aqueous solution are indicated by change of electronic spectrum and induction of circular dichroism. Dimerization constant of porphyrin and complex formation constant of porphyrin with cyclodextrin are also determined from the electronic spectra.

Aspiration biopsy cytology (ABC) was done on one hundred and forty-five patients with cervical tumors, excluding primary tumors of the thyroid and local metastasis of thyroid cancer, during the period of 44 months from 1981-85. Surgery was done on a total of fifty-five patients with lesions evaluated to be malignant and requiring resection. A correlation was determined between the histological diagnosis based on permanent paraffin sections and the diagnosis made by aspiration biology cytology in order to evaluate ABC in terms of accuracy together with its complications and limitations. The false positive rate was 6.6 per cent and the false negative rate was 8.3 per cent. Histologic diagnosis was predictable by ABC in eighty per cent of cases, but difficulty was experienced in predicting the histologic diagnosis in cases of a poorly differentiated malignancy. A few cases of slight subcutaneous bleeding occurred, but seeding implantation of cancer cells was nil. It was confirmed that ABC is a highly diagnostic procedure for assessing cervical tumors. The method is simple, safe and economical.

Therapeutic principle and problems in the treatment of gallbladder cancer were studied on the basis of operative results in 24 patients with resected gallbladder cancer (rate of resection: 55.8%). According to macroscopic findings, tumor size and infiltration into the surrounding region tended to increase with the depth of invasion. In terms of cancerous extension, no metastasis or infiltration was found in patients with m or pm cance, while patients with cancer of ss or higher stage had the highest frequency of lymph node metastasis, followed by intrahepatic direct infiltration and bile duct infiltration, in that order. Patients with s cancer presented particularly high levels of extension. Studies of surgical procedure in relation to prognosis indicated that simple cholecystectomy (R2) may be required for treating patients with pm cancer bacause recurrent cases were found among them and intraoperative differential diagnosis remains difficult. Patients with as cancer presented various patterns of extension and stage of progression, achieving ling-term survival in some cases. Improved prognosis may be expected by actively applying extended operation (R2-3) according to the stage of progression. Cases with s cancer showed poor prognosis irrespective of surgical procedure, indicating the need for careful consideration in applying extended operation.-60-

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