β-Catenin is a multi-functional protein involved in cell adhesion and signal transduction and has a critical role in colorectal cancer development. β-Catenin positively regulates the aryl-hydrocarbon receptor (AhR) mediated signal by both induction of AhR expression and enhancement of AhR-dependent gene induction. Conversely, it was reported that AhR negatively regulates the β-catenin signal via ubiquitination and subsequent degradation in a ligand dependent manner. However, there have been conflicting data among previous studies regarding the relationship between these two proteins. In this report, we conducted confirmatory studies dissecting the relationship between AhR and β-catenin. We did not observe β-catenin degradation by AhR ligands in several colon cancer cell lines. Reporter assays revealed that the AhR ligand did not alter TcF/β-catenin dependent transcription. Yeast and mammalian two-hybrid assays failed to reconstruct the interaction of β-catenin and AhR even when other factors, Arnt, CUL4B, and DDB1, were co-expressed additionally. Independently to induction of AhR expression, β-catenin enhanced AhR-dependent transcriptional activation via the xenobiotic response element (XRE). Coimmunoprecipitation detected the formation of a β-catenin and ligand-activated AhR complex, which was thought to reflect the β-catenin mediated enhancement of the AhR signaling. Overall, we could only confirm unidirectional interaction, which is positive regulation of the AhR signal by β-catenin. These results suggested that data from previous reports on the degradation of β-catenin via liganded AhR warrants further investigation to yield clarity in the field.

We present the case of a patient with low-grade non-intestinal-type adenocarcinoma (non-ITAC) of the nasal cavity, which is a very rare tumor. A 62-year-old female visited another hospital due to nasal obstruction on the left side. Adenocarcinoma of the nasal cavity was suspected, and she visited our department for detailed examination and treatment. A tumor was observed from the left inferior meatus to the common nasal meatus. Contrast-enhanced CT/MRI showed a neoplastic lesion with a mild contrast-enhancing effect localized in the nasal cavity. Under the diagnosis of left nasal adenocarcinoma cT1N0M0, we performed endoscopic tumor resection under general anesthesia. Histopathologic examination of the tumor showed low-grade non-ITAC. The margins were negative and no additional treatment was performed. No local recurrence or metastasis was observed 12 months postoperatively.

No abstract

We examined 365 patients who underwent surgery for thyroid lesion at our institution during the nine years from July 2012 to September 2021. There were 112 benign lesions and 253 malignant tumors. The accurate diagnosis rate of fine-needle aspiration cytology (FNAC) was 91.7％ . 76.4％ of Class 3 cases that received FNAC were malignant tumors. Postoperative recurrent laryngeal nerve palsy (RLNP) was observed in 20 case, of which 16 case were transient and 4 case were permanent. We examined the postoperative complications of RLNP regarding factors of age, gender, surgical side, histological type, the presence or absence of cervical lymph node dissection, and size. The frequency of RLNP increased in cases who were 55 years old and over, bilateral side, malignant tumor and cervical lymph node dissection.

No abstract